Tumor infiltrating lymphocyte grade as prognostic factor of recurrence in molecular subtypes of breast cancer (triple negative and Her2): Narrative Review

Abstract

Breast cancer is a common disease affecting women, with significant health-related adverse effects. Tumor-infiltrating lymphocytes (TILs) are recognized as manifestations of the host's antitumor immunity. The following study reviews and summarizes published reports on the effectiveness of high levels of tumor-infiltrating lymphocytes on the prognosis of triple-negative and HER2-enriched breast cancer molecular subtypes. Studies and reviews in English from PubMed were included. A higher percentage of tumor-infiltrating lymphocytes is associated with a better prognosis and survival rate of triple-negative and HER2 -enriched breast cancer. Consequently, such histological markers should be routinely used in the microscopic analysis of breast biopsies.