Incidence of deep vein thrombosis in patients diagnosed with utero-ovarian neoplasms: A single center study

Abstract

Introduction: Venous thrombus embolism (VTE), a frequent complication in patients with gynecological cancer. The objective of the study was to determine the incidence of deep VTE in patients diagnosed with uterine-ovarian neoplasms in an oncology referral center in Guayaquil-Ecuador in 2019.

Methodology: The present observational study, from a retrospective source, was carried out in the statistics service of the National Oncological Institute “Dr. Juan Tanca Marengo” from the Society for the Fight Against Cancer-SOLCA, Guayaquil Ecuador. The calculation of the sample size was probabilistic of 237 patients. Cases of patients with uterine-ovarian and endometrial neoplasms were included. The variables were age, location of the neoplasm, incidence of VTE based on ultrasound evidence of VTE, Wels criteria, D-dimer. Descriptive statistics were used. The percentages are presented with a confidence interval.

Results: 237 patients were included, the most frequent age group 40 to 59 years with 46.4%, followed by 60 and over with 34.6%; 88.6% of the cases had uterine cancer (cervix - endometrium) and 11.4% with ovarian cancer. According to the Wells classification, 92% had a moderate risk of DVT and 8% had a high risk. The incidence of deep vein thrombosis in patients with uterine-ovarian cancer was 6.75% (CI 6.54-6.96%). The incidence was statistically more prevalent (P=0.01) in the group of women with Uterus Ca than in the ovarian Ca group.

Conclusion: Utero-ovarian neoplasms have a high incidence of deep vein thrombosis.