Case report: Veno-Occlusive liver disease secondary to Chemotherapy in a patient with Ewing's Sarcoma.

Abstract

Introduction: Hepatic Veno-occlusive Disease or Sinusoidal Obstruction Syndrome is a clinical syndrome characterized by painful hepatomegaly, jaundice, ascites, edema and weight gain, which usually occurs as a complication of bone marrow transplantation.

Clinical Case: We describe a new case of male school age 9 with Ewing Sarcoma who had Hepatic Veno-occlusive Disease secondary to chemotherapy with cyclophosphamide and vincristine.

Evolution: We set the differential diagnosis from liver damage due to infection and autoimmune diseases through serological tests and biopsy.

Conclusion: This is the first report that describes the association between Ewing Sarcoma and Hepatic Veno-occlusive Disease.