Abstract
Introduction: The implementation of molecular tests for the detection of hrHPV infection has generated changes in the screening guidelines in the timely detection of cervical carcinoma. The aim of the study is to present the sensitivity and specificity of cytological studies and molecular tests with histological studies.
Methods: A cross-sectional, retrospective study was carried out in the Solca-Quito hospital from January to December 2014. Cases were collected with cervical cytological diagnoses, the results of the real-time PCR test of hrHPV (Hibribio®) and the diagnoses Histopathological findings in patients who underwent a biopsy. The analysis performed was "diagnostic test" to measure the sensitivity and specificity of the tests.
Results: 730 molecular studies of hrHPV in conjunction with cytological studies were performed. The positive cases for hrHPV were 301/730 cases (41.2 %). The majority of hrHPV positive cases correspond to genotypes 16/18 (59.5 %) and are in the age ranges between 30 and 49 years (58.8 %). In 168 cases, a histopathological study was also carried out, in which the sensitivity (S) of the cytology Vs Histology was determined, which was 76 %, the specificity (E) was 48 %, with a positive predictive value (PPV) of 90 % The S of HrHPV vs Histology was 74%, E 39%, PPV 89 %; S for Cytology + HrHVP vs Histology was 91 %, E 40 %, PPV 90 %.
Conclusion: The highest sensitivity for the diagnosis of cervical cancer is the completion of Cytology and the presence of HrHVP. The highest specificity was obtained with the Cytology study.