Innovation and Equity in Breast Cancer. HER2-Low: A Real Opportunity or a Mirage for Low- and Middle-Income Countries?

Published

2025-12-15

How to Cite

Escala Cornejo, R. A. (2025). Innovation and Equity in Breast Cancer. HER2-Low: A Real Opportunity or a Mirage for Low- and Middle-Income Countries?. Oncology Journal (Ecuador), 35(3), 1–2. https://doi.org/10.33821/383

Authors

DOI:

https://doi.org/10.33821/383

Abstract

Equity in breast cancer treatment in the era of innovation is one of the greatest public?health challenges,
particularly in low- and middle-income countries (LMICs). While the past two decades have brought notable
advances in diagnosis, targeted therapies, and precision medicine, gaps between population groups, geographic
regions, and socioeconomic strata remain profound [1]. Likewise, multiple recent studies indicate that these
inequities appear as differences in stage at diagnosis, lower access to mammography, and greater difficulty
receiving standard treatments ultimately translating into lower survival rates.

Downloads

Download data is not yet available.

Author Biography

Roberto A. Escala Cornejo, Sociedad Ecuatoriana de Oncología

Clinical oncologist; President, Ecuadorian Society of Oncology – Guayas Chapter

References

Arrey EN, GoPaul D, Anderson D, Okoli J, McKenzie-Johnson T. Addressing breast cancer disparities: a comprehensive approach to health equity. J Surg Oncol. 2024. https://doi.org/10.1002/jso.28011. PMID:39699972

Williams DR, Yao X, Mohammed SA, et al. Disparities in breast cancer outcomes by race/ethnicity and socioeconomic status: a population-based cohort study. J Natl Cancer Inst. 2021;113(12):1645-1655. PMID:33534484

Trapani D, Murthy SS. Progress in global breast cancer control. Curr Opin Oncol. 2025. https://doi.org/10.1097/CCO.0000000000001163

Modi S, Jacot W, Yamashita T, et al. Trastuzumab Deruxtecan in previously treated HER2-low advanced breast cancer. N Engl J Med. 2022. https://doi.org/10.1056/NEJMoa2203690

Liu Y. HER2-low breast cancer: insights on pathological testing. Transl Breast Cancer Res. 2023. https://doi. org/10.21037/tbcr-23-15. PMID:11093042

Gobbi H, Carvalho FM, De Brot M, et al. Challenges in the evaluation of HER2 and HER2-low in breast cancer in Brazil. Rev Assoc Med Bras. 2024. https://doi.org/10.1590/1806-9282.20240313. PMID: PMC11444227

Fundytus A, Sullivan R, Vanderpuye V, et al. Access to cancer medicines deemed essential by oncologists in 82 countries: an international, cross-sectional survey. Lancet Oncol. 2021;22(10):1367-1377. https://doi. org/10.1016/S1470-2045(21)00463-0

Agbedinu K, Antwi S, Aduse-Poku L, et al. A scoping review on barriers to cancer diagnosis and care in low- and middle-income countries. Cancer Epidemiol Biomarkers Prev. 2025. https://doi.org/10.1158/1055-9965. EPI-25-0120. PMID:40304503

International Agency for Research on Cancer. Global Cancer Observatory: Ecuador — Fact sheet. Lyon (FR): IARC; 2022. Available at: https://gco.iarc.who.int/media/globocan/factsheets/populations/218-ecuador-fact-sheet.pdf. Accessed December 5, 2025