Abstract
Introduction: The objective of this study was to determine the clinical characteristics and prognosis of patients with adult T-cell leukemia/lymphoma (ATL) at the National Institute of Neoplastic Diseases (INEN) of Peru.
Methodology: A cross-sectional study was carried out, which included 188 clinical histories and a pathological study of patients diagnosed with HTLV-1 infection diagnosed at the INEN for ten years, of whom 150 had ATL.
Results: Sixty-two percent of the patients had the ATL lymphoma subtype, 37% had the acute subtype, and 1% had the chronic subtype. The median age was 53 (20-89); 51% were women. Within the clinical characteristics: ECOG >or =2 (56%); clinical stage III-IV (80%), symptoms B (58%); increased lactic dehydrogenase, LDH, (74%); leukocytosis (50%); hypercalcemia (46%) and anemia (36%). A total of 122 patients (81.3%) received treatment, 79% with chemotherapy (CT) and 4.6% with complementary radiotherapy (RT); CHOP was the most frequent QT regimen (89%). Of the patients with QT, 18% had CR, 32% PR, 7% EE, and 13% PE.
Conclusion: In this report, in patients with ATL, the lymphoma form was the most frequent subtype, and there was a high prevalence of atypical immunophenotype and poor response to CHOP.
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Copyright (c) 2022 Natalia Valdivieso Lama, Carlos Barrionuevo Cornejo, Judith Vidal Ayllon, Luis Casanova Marquez, Claudio Flores Flores, Lourdes López Chavez, Cindy Alcarraz Molina, Rossana Ruiz Mendoza, Shirley Quintana Truyenque