Abstract
Introduction: Lymphoproliferative Syndromes are neoplastic processes that originate in the lymphoid tissue, both central and peripheral. The presentation of non-Hodgkin lymphomas of the breast is infrequent, which is why a series of cases of this pathology is presented at a national cancer center in Havana-Cuba.
Methods: The present observational, retrospective study was conducted at the National Institute of Oncology of Cuba. Clinical histories and pathological anatomy records of patients with breast cancer were reviewed from the National Institute of Oncology and Radiobiology of Cuba, from the periods of January 1980 to December 2010. The type of sampling was non-probabilistic of convenience. The variables studied were sex, age, anatomopathological diagnosis, location of the lesions and survival. Descriptive statistics are used for descriptive data and Kaplan Meier for the survival report.
Results: We analyzed 14 records of female patients with an average age of 54.7 ± 18 years. The average symptom duration was 9.2 ± 18 months. 13 cases were located in the right breast (92.86%). In ten cases (71.53%) they presented with a clinical stage I. The most prevalent histopathological diagnosis was that of diffuse large non-Hodgkin lymphoma (NHL) of B cells with 3 cases (21.4%) and mixed diffuse NHL of small and large cells cleft with 3 cases (21.4%). Thirteen of the cases (92.86%) underwent mastectomy surgery, 13 cases (92.86%) underwent chemotherapy and in 6 cases (42.86%) radiotherapy sessions were applied. The survival of the group of patients was reported in 74 ± 16.5 months, (95% CI 41.6 - 106.4).
Conclusion: In this case series presented the incidence of non-Hodgkin's lymphoma of the breast was 14 cases, the large percentage in the right breast, the survival of the group of patients was 70 months. The prevalent histology was B cells and mixed diffuse non-Hodgkin lymphoma of small and large cells cleaved.